Okay, so this is possible? I can create a new neighborhood and Uni campus, then use the deleteallcharecters cheat to get rid of the "undesireables." Go into Uni, populate it with 15 male and 15 female of my own creation. They will be the founding mothers and fathers.
But, the game will spawn repairmen, maids, gardeners, and other service NPC's when needed. And I can choose to ignore them, of course.
But, then again, when Nightlife comes out, I'll have my "virgin" neighborhood crawling with disco bunnies and lounge lizards and wanna-be Lestats, won't I?