This happened when I tried to use the Mod Organizer from MTS2, I ditched that and reinstalled the framework (with Delphys program), then put everything back. That helped.
Well, I doubt that is my problem, because I haven't heard of this Mod Organizer, and I didn't have Framework (or any downloads or mods) installed the first time I to run the game.
So far I've tried deleting Awesomemod and all Cache files, and running on minimum settings. I can't think what else I could try that might work.