Ah well, that's life. I've done a bit of further research, and the bug I'm experiencing is a somewhat well known one, but the main cause of it is WA, which I don't have. Maybe it's mod interaction or maybe it's possible that the version mismatch might have caused some borkiness. Maybe I'll attempt Awesome again at some future date after I get to know my modlist and its quirks a bit better. At any rate, cheers, and good luck to anyone else who has been hit with the bludgeon of Origin.

Same issue as that guy earlier. Time issues at first, with the clock frozen on Sunday morning, and time based events like going to work failing to occur. I attempted to quit and reload to see if that would help, but instead when I loaded the save, both my sims were missing from the family portrait, leaving behind motionless versions of themselves which could not be interacted with in any way. The sim who had been sleeping was there in the bed, motionless, while the Zs animated above her. When I went to Edit Town, the household was marked as unoccupied. Attempting to play a new household resulted in the same issue the next time I loaded up the game. I did try creating a new household and save-quitting as soon as they moved in, but when I loaded that one up there weren't any issues, so it seemed to be something that went wrong over the course of a couple of hours. I should note that the time issue seemed to be fixed by reloading so it's likely a separate problem to the sim disappearance. Reset all sims cheat didn't do anything. I didn't try anything other than that.

Version tag file says this:
[Version]
LatestBase = 1.69.36.024017
Same thing appears on the bottom of my launcher.
Searching google for 'Sims 3 1.69' seems to return results consistent with this update having occurred on the twelfth of this month, so perhaps the game updates page hasn't been updated with it yet.

I was originally using the 'hit ignore' approach, but I was experiencing some pretty severe and relatively consistent bugs which led me to believe that this was a bad idea. Game explosion without Awesomemod seems to have been fixed by uninstalling base game and reinstalling. Still, I'd really rather play with Awesomemod if possible.

I was under the impression that Awesomemod gets updated for new versions. Was I wrong, or would a hypothetically updated Awesomemod simply not solve the issues because Origin sucks?
There's also the fact that removing awesomemod from my computer seems to cause Sims 3 to completely fail at the starting up thing. I suspect a reinstall may be in order.

I'm going to assume that the non-critical core mismatch messages and the terrible terrible bugging I've had are due to the fact that I have version 1.69, while Awesomemod only seems to be up to 1.67 in terms of compatibility. Any idea of when the next version will be out? Reverting to 1.67 is unfortunately not on option; I only have the game on Origin and it refuses to install anything other than the sparkling new version.