I have been having a lot of problems recently with error 12 and 13, but what is even more infuriating are the crashes during a save!
I downloaded and installed CFF Explorer last night - I have Windows 7, 64 bit with 8 gb of RAM. This morning I played for a while, and of course I'm still in the habit of saving every 10-15 minutes, usually with the 2nd or 3rd save CTD on me - but surprisingly, I was able to play for about 2 hours, doing multiple saves without any problems at all! Btw, when I say I played for 2 hours - I chose to quit, it wasn't forced upon me. Been a long while since that's happened.
Thanks for posting this potential fix - I hope I don't jinx myself by saying this but it seems to have made a positive difference. I can play again!