I just recently began to get these errors. I sent my sim off to work, and while there I had her "meet other coworkers". Immediately after this, the FSE popped up-I was unable to save the game, so I just exited out of it. As far as mods I have one set of default skins and eyes, a handful of patterns,  and the latest version of AwesomeMod. Base game, store bought, and it has been patched up to 1.10
I also always make sure to clear out cache files before starting up a new game.

Here's what the error looks like{it's huge}:
http://farm5.static.flickr.com/4022/4452723012_dfb605f004_o.jpg

Any help would be greatly appreciated