Thanks everyone for your help.

Removing Inseminator did the trick.  I haven't  installed the new one or tried installing the old one yet. But it most definitely was Inseminator causing the problem.

Thank you Hairfish!! 

Gali, thank you for the link!

That's exactly what it says and it has a little pic of the sim in the box. After clicking no about 30 times in a row just trying to exit the game I did click yes and he died.

The grim reaper came in and there was a message that no one lived there.

Gail, I believe I have the oldest version too but I think I'll just remove it and see what happens. I'll try anything at this point. If I redownload, which version should I try if this is the problem?

Yes, I have  InSIMinator. Could that be it?

I keep getting this message over and over whenever I enter a house. If I click no, it just pops back up again. I tried entering houses pre Nightlife and same thing happens. It happens to every sim I have, even new ones.

I've run clean installer about three times and nothing shows up. It didn't happen as soon as I installed nightlife, this is something new. I've deleted all my recent downloads.  I installed  the patch and it still keeps happening.

Any ideas? I can't play the game at all.

Thanks!